Intercalation-Activated Layered MoO3 Nanobelts as Biodegradable Nanozymes for Tumor-Specific Photo-Enhanced Catalytic Therapy

Zhan Zhou; Yanlong Wang; Feng Peng; Fanqi Meng; Jiajia Zha; Lu Ma; Yonghua Du; Na Peng; Lufang Ma; Qinghua Zhang; Lin Gu; Wenyan Yin; Zhanjun Gu; Chaoliang Tan

doi:10.1002/anie.202115939

Intercalation-Activated Layered MoO₃ Nanobelts as Biodegradable Nanozymes for Tumor-Specific Photo-Enhanced Catalytic Therapy

Angew Chem Int Ed Engl. 2022 Apr 11;61(16):e202115939. doi: 10.1002/anie.202115939. Epub 2022 Feb 11.

Authors

Zhan Zhou^{1

2}, Yanlong Wang^{3

4}, Feng Peng⁵, Fanqi Meng⁶, Jiajia Zha⁷, Lu Ma⁸, Yonghua Du⁸, Na Peng⁴, Lufang Ma¹, Qinghua Zhang^{6

9}, Lin Gu^{6

9}, Wenyan Yin³, Zhanjun Gu³, Chaoliang Tan^{7

10}

Affiliations

¹ College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang, 471934, P. R. China.
² People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, 450003, P. R. China.
³ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, P. R. China.
⁴ Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, Hubei, 430081, P. R. China.
⁵ College of Physics and Electronic Information & Henan Key Laboratory of Electromagnetic Transformation and Detection, Luoyang Normal University, Luoyang, 471934, P. R. China.
⁶ Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
⁷ Department of Electrical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, P. R. China.
⁸ National Synchrotron Light Source II, Brookhaven National Laboratory Upton, Upton, NY 11973, USA.
⁹ School of Physical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
¹⁰ Shenzhen Research Institute, City University of Hong Kong, Shenzhen, 518057, P. R. China.

PMID: 35080098
DOI: 10.1002/anie.202115939

Abstract

The existence of natural van der Waals gaps in layered materials allows them to be easily intercalated with varying guest species, offering an appealing strategy to optimize their physicochemical properties and application performance. Herein, we report the activation of layered MoO₃ nanobelts via aqueous intercalation as an efficient biodegradable nanozyme for tumor-specific photo-enhanced catalytic therapy. The long MoO₃ nanobelts are grinded and then intercalated with Na⁺ and H₂ O to obtain the short Na⁺ /H₂ O co-intercalated MoO_3-x (NH-MoO_3-x ) nanobelts. In contrast to the inert MoO₃ nanobelts, the NH-MoO_3-x nanobelts exhibit excellent enzyme-mimicking catalytic activity for generation of reactive oxygen species, which can be further enhanced by the photothermal effect under a 1064 nm laser irradiation. Thus, after bovine serum albumin modification, the NH-MoO_3-x nanobelts can efficiently kill cancer cells in vitro and eliminate tumors in vivo facilitating with 1064 nm laser irradiation.

Keywords: Catalytic Therapy; Intercalation; Layered MoO3; Nanozymes; Tumor-Specific.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Catalysis
Humans
Neoplasms*
Oxides* / chemistry
Reactive Oxygen Species
Water

Substances

Oxides
Reactive Oxygen Species
Water