Systemic treatment for triple negative breast cancer in older patients: A Young International Society of Geriatric Oncology Review Paper

Wing-Lok Chan; Joana Marinho; Yanin Chavarri-Guerra; Jacobo Hincapie-Echeverri; Rogelio N Velasco Jr; Baran Akagunduz; Mukul Roy; Wing Tung Gobby Kwong; Wing-Fong Wu; Nicolò Matteo Luca Battisti; Enrique Soto-Perez-de-Celis

doi:10.1016/j.jgo.2022.01.002

Systemic treatment for triple negative breast cancer in older patients: A Young International Society of Geriatric Oncology Review Paper

J Geriatr Oncol. 2022 Jun;13(5):563-571. doi: 10.1016/j.jgo.2022.01.002. Epub 2022 Jan 23.

Affiliations

¹ Department of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R. Electronic address: winglok@hku.hk.
² Department of Medical Oncology, Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal; Associação de Investigação de Cuidados de Suporte em Oncologia (AICSO), Portugal.
³ Department of Hemato-Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
⁴ Department of Hematology/Oncology, University of Florida, USA.
⁵ Department of Clinical Epidemiology, University of the Philippines, Manila, Philippines.
⁶ Department of Medical Oncology, Erzincan Binali Yildirim University Medical School, Erzincan, Turkey.
⁷ Jaslok Hospital & Research Centre, Mumbai, India.
⁸ Department of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R.
⁹ LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
¹⁰ Breast Unit - Department of Medicine, The Royal Marsden NHS Foundation Trust, United Kingdom; Breast Cancer Research Division, The Institute of Cancer Research, London, United Kingdom.
¹¹ Department of Geriatrics, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.

PMID: 35078741
DOI: 10.1016/j.jgo.2022.01.002

Abstract

Breast cancer is the most common type of cancer affecting women worldwide and its risk increases with age. Compared with other breast cancer subtypes, triple negative breast cancer (TNBC) behaves more aggressively, with earlier relapses and poorer survival outcomes. Although the incidence of TNBC decreases with age, it still affects about 10% of older women with breast cancer. The management of TNBC in older patients is particularly challenging as chemotherapy is the main treatment choice in both early and advanced diseases and older patients are often prone to increased treatment-related toxicities. This review highlights the specific considerations in this vulnerable group of patients and summarizes the current evidence for TNBC management in older adults from early to late stage of disease.

Keywords: Assessment; Chemotherapy; Geriatric assessment; Immunotherapy; Older patients; Triple negative breast cancer.

Publication types

Review

MeSH terms

Aged
Female
Humans
Triple Negative Breast Neoplasms* / drug therapy