A Rare Case of Epstein-Barr Virus-Positive T-Cell Lymphoma in the Skin of an Immunocompromised Patient

Am J Dermatopathol. 2022 Feb 1;44(2):e19-e22. doi: 10.1097/DAD.0000000000002048.

Abstract

Immunodeficiency-associated lymphoproliferative disorders are associated with latent infection by Epstein-Barr virus (EBV). Most cases of EBV-positive immunodeficiency-associated lymphoproliferative disorders arise from B cells, although some are of T-cell or natural killer origin. Cutaneous involvement is unusual and sporadically reported in the literature. We describe a rare case of an EBV-positive T-cell lymphoma presenting in the skin of a 32-year-old woman using adalimumab for neurosarcoidosis.

Publication types

  • Case Reports

MeSH terms

  • Adalimumab / adverse effects
  • Adult
  • Epstein-Barr Virus Infections / pathology
  • Epstein-Barr Virus Infections / virology*
  • Fatal Outcome
  • Female
  • Herpesvirus 4, Human
  • Humans
  • Immunocompromised Host / drug effects
  • Lymphoma, T-Cell, Cutaneous / pathology*
  • Lymphoma, T-Cell, Cutaneous / virology
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / virology
  • Tumor Necrosis Factor Inhibitors / adverse effects

Substances

  • Tumor Necrosis Factor Inhibitors
  • Adalimumab