Biomimetic platelet membrane-coated nanoparticles for targeted therapy

Huijie Han; Raquel Bártolo; Jiachen Li; Mohammad-Ali Shahbazi; Hélder A Santos

doi:10.1016/j.ejpb.2022.01.004

Biomimetic platelet membrane-coated nanoparticles for targeted therapy

Eur J Pharm Biopharm. 2022 Mar:172:1-15. doi: 10.1016/j.ejpb.2022.01.004. Epub 2022 Jan 22.

Authors

Huijie Han¹, Raquel Bártolo², Jiachen Li¹, Mohammad-Ali Shahbazi³, Hélder A Santos⁴

Affiliations

¹ Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, P.O Box 56, FI-00014 Helsinki, Finland; W.J. Kolff Institute for Biomedical Engineering and Materials Science, University of Groningen/University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands.
² Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, P.O Box 56, FI-00014 Helsinki, Finland; School of Pharmacy, University of Eastern Finland, 70211 Kuopio, Finland; W.J. Kolff Institute for Biomedical Engineering and Materials Science, University of Groningen/University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands.
³ Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands; W.J. Kolff Institute for Biomedical Engineering and Materials Science, University of Groningen/University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands.
⁴ Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, P.O Box 56, FI-00014 Helsinki, Finland; W.J. Kolff Institute for Biomedical Engineering and Materials Science, University of Groningen/University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands. Electronic address: h.a.santos@umcg.nl.

PMID: 35074554
DOI: 10.1016/j.ejpb.2022.01.004

Abstract

The development of cell membrane-modified biomimetic nanoparticles has extensively increased during the past years due to their exceptional biocompatibility, evasion from the immune system, and targeting ability. Known as a cutting-edge area of research in nanomedicine, such novel nanoplatforms can mimic different functions of the primary cells, while successfully delivering their cargos to the defect site with the aim of enhancing the therapeutic responses and reducing the side effects. Platelet is a key factor for haemostasis and a major player in wound healing, inflammation, and many other biological functions and pathological conditions. As a highly responsive cell, platelets can adapt to environment modifications and release several soluble biomolecules, such as growth factors, coagulant factors, and extracellular vesicles. Additionally, platelets are capable of immune system evasion, sub-endothelial adhesion, and pathogen interaction. These characteristics have inspired the design of several platelet membrane-coated nanoparticles as drug delivery systems. This review describes the current developments in platelet membrane-coated nanoparticles for targeted therapy, specifically, their advantages compared to other biomimetic cell-derived nanoparticles and their applicability in the medical field are elucidated. Finally, the challenges and future perspectives associated with this nanoplatform are summarised.

Keywords: Biomedical applications; Biomimetic nanoparticles; Cell-derived materials; Nanomedicine; Platelet membrane; Targeted therapy.

Publication types

Review

MeSH terms

Biomimetic Materials*
Biomimetics
Blood Platelets
Cell Membrane
Drug Delivery Systems
Nanoparticles*