Synchronous biliary gallstones and colorectal cancer: A single center analysis

Narcis Octavian Zarnescu; Eugenia Claudia Zarnescu; Ioana Dumitrascu; Alexandru Chirca; Nicoleta Sanda; Andreea Iliesiu; Radu Costea

doi:10.3892/etm.2021.11061

Synchronous biliary gallstones and colorectal cancer: A single center analysis

Exp Ther Med. 2022 Feb;23(2):138. doi: 10.3892/etm.2021.11061. Epub 2021 Dec 13.

Authors

Narcis Octavian Zarnescu^{1

2}, Eugenia Claudia Zarnescu^{1

2}, Ioana Dumitrascu², Alexandru Chirca^{1

2}, Nicoleta Sanda^{1

2}, Andreea Iliesiu^{3

4}, Radu Costea^{1

2}

Affiliations

¹ Department of Surgery, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
² Second Department of Surgery, University Emergency Hospital, 050098 Bucharest, Romania.
³ Department of Pathology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
⁴ Department of Pathology, University Emergency Hospital, 050098 Bucharest, Romania.

Abstract

Gallstones and colorectal cancer (CRC) are two common disorders that may develop simultaneously. In such situations, there is a significant chance of missing one of the conditions due to the primary clinical presentation. Late detection, diagnosis and treatment can be especially problematic in the case of unrecognized CRC. In the present study, the medical charts were retrospectively reviewed for all consecutive patients who were treated in the Second Department of Surgery, University Emergency Hospital Bucharest (Romania) between February 2015 and December 2017 following a diagnosis of CRC and/or biliary stones. There were 203 patients with CRC, 433 with biliary gallstones and 19 patients with both conditions. There were 125 men (61.6%) in the CRC group and 138 men (31.9%) in the gallstone group. The average age was 54.1±15.9 years in the gallstone group and 66.1±11.6 years in the CRC group. Obesity was observed in 96 patients (22.2%) with gallstones and in 14 (6.9%) patients in the CRC group. In the CRC group, 80 patients had medical comorbidities (39.4%), while in the gallstone group 126 patients (29.1%) had medical comorbidities. Bivariate analysis comparing gallstone only vs. gallstone and CRC identified age (P=0.001), male sex (P=0.001) and thyroid disease (P=0.001) as significant factors associated with synchronous diagnosis. The multivariable logistic regression of factors predicting CRC in patients with gallstones identified age (OR, 1.06; 95% CI, 1.023-1.105; P=0.002) and thyroid diseases (OR, 11.15; 95% CI, 2.532-49.06; P=0.001) as independent factors. There were significant differences regarding the location of the tumor between the CRC-only group and the gallstone and CRC group (P=0.001): Rectum (39.7 vs. 5.3%), left colon (26.6 vs. 21.1%), transverse colon (13 vs. 26.3%) and right colon (20.7 vs. 47.4%). The study concluded that, in patients with gallstones, age and thyroid conditions were significantly associated with CRC. Patients with a synchronous diagnosis of gallstones and CRC had significantly more right-sided CRC compared with regular CRC.

Keywords: colorectal cancer; comorbidity; epidemiology; gallstones; right-sided colon cancer; surgery; synchronous.

Grants and funding

Funding: No funding was received.