Electrophysiological resting state brain network and episodic memory in healthy aging adults

Yuxuan Chen; Julia H Tang; Lisa A De Stefano; Michael J Wenger; Lei Ding; Melissa A Craft; Barbara W Carlson; Han Yuan

doi:10.1016/j.neuroimage.2022.118926

Electrophysiological resting state brain network and episodic memory in healthy aging adults

Neuroimage. 2022 Jun:253:118926. doi: 10.1016/j.neuroimage.2022.118926. Epub 2022 Jan 20.

Authors

Yuxuan Chen¹, Julia H Tang², Lisa A De Stefano³, Michael J Wenger³, Lei Ding⁴, Melissa A Craft⁵, Barbara W Carlson⁵, Han Yuan⁶

Affiliations

¹ School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK, United States.
² Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United States.
³ Department of Psychology, University of Oklahoma, Norman, OK, United States; Graduate Program in Cellular and Behavioral Neurobiology, University of Oklahoma, Norman, OK, United States.
⁴ Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United States; Institute for Biomedical Engineering, Science, and Technology, University of Oklahoma, Norman, OK, United States.
⁵ Fran and Earl Ziegler College of Nursing, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
⁶ Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United States; Institute for Biomedical Engineering, Science, and Technology, University of Oklahoma, Norman, OK, United States. Electronic address: hanyuan@ou.edu.

PMID: 35066158
DOI: 10.1016/j.neuroimage.2022.118926

Abstract

Recent studies have emphasized the changes in large-scale brain networks related to healthy aging, with the ultimate purpose to aid in differentiating normal neurocognitive aging from neurodegenerative disorders that also arise with age. Emerging evidence from functional Magnetic Resonance Imaging (fMRI) indicates that connectivity patterns within specific brain networks, especially the Default Mode Network (DMN), distinguish those with Alzheimer's disease from healthy individuals. In addition, disruptive alterations in the large-scale brain systems that support high-level cognition are shown to accompany cognitive decline at the behavioral level, which is commonly observed in the aging populations, even in the absence of disease. Although fMRI is useful for assessing functional changes in brain networks, its high costs and limited accessibility discourage studies that need large populations. In this study, we investigated the aging-effect on large-scale networks of the human brain using high-density electroencephalography and electrophysiological source imaging, which is a less costly and more accessible alternative to fMRI. In particular, our study examined a group of healthy subjects in the age range from middle- to older-aged adults, which is an under-studied range in the literature. Employing a high-resolution computation model, our results revealed age associations in the connectivity pattern of DMN in a consistent manner with previous fMRI findings. Particularly, in combination with a standard battery of cognitive tests, our data showed that in the posterior cingulate / precuneus area of DMN higher brain connectivity was associated with lower performance on an episodic memory task. The findings demonstrate the feasibility of using electrophysiological imaging to characterize large-scale brain networks and suggest that changes in network connectivity are associated with normal aging.

Keywords: Aging; EEG; Functional connectivity; Memory; Resting state network; Source imaging.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Adult
Brain / diagnostic imaging
Brain / physiology
Brain Mapping
Healthy Aging*
Humans
Magnetic Resonance Imaging
Memory, Episodic*
Middle Aged
Nerve Net / diagnostic imaging
Neural Pathways / physiology