Immunotherapy for Gastroesophageal Tumors: Is there still Hope for Efficacy?

Abstract

Immunotherapy represents one of the biggest breakthroughs of the 21st century and redefined modern cancer treatment. Despite this new approach changing the treatment paradigm in various cancer entities, including lung and head-and-neck cancer, the efficacy of these treatment regimens varies in different patient subgroups, and so far, these treatment regimens have failed to meet the high expectations of gastroesophageal cancer patients. This review discusses new treatment approaches concerning immunotherapy in gastroesophageal cancer patients and sheds some light on ongoing trials and new treatment combinations.

Keywords: Esophageal neoplasm; esophageal cancer; gastric cancer; gastroesophageal cancer; immunogenic cell death; immunotherapy; stomach neoplasm.