De-Escalation of Breast Cancer Surgery Following Neoadjuvant Systemic Therapy

Umar Wazir; Kefah Mokbel

doi:10.4274/ejbh.galenos.2021.2021-5-4

De-Escalation of Breast Cancer Surgery Following Neoadjuvant Systemic Therapy

Eur J Breast Health. 2021 Dec 30;18(1):6-12. doi: 10.4274/ejbh.galenos.2021.2021-5-4. eCollection 2022 Jan.

Authors

Umar Wazir^{1

2}, Kefah Mokbel¹

Affiliations

¹ London Breast Institute, Princess Grace Hospital, London, United Kingdom.
² Department of General Surgery, Khyber Teaching Hospital, Peshawar, Pakistan.

Abstract

Breast cancer treatment has seen many advances in recent decades, lessening the morbidity to patients, while improving outcomes. Central to these gains has been the introduction of breast conserving surgery and neoadjuvant systemic therapy (NST). There is a considerable interest in further de-escalation of the treatment of breast cancer, which is being studied in several ongoing randomised trials. We aimed to appraise the current literature regarding the various aspects of de-escalation of surgical treatment of breast cancer after NST, and attempt to prognosticate the future course of breast oncotherapy.

Keywords: Breast cancer; de-escalation; neo-adjuvant therapy.

Publication types

Review