Twelve years ago, the first free electron laser for hard X-rays (XFEL), the Linac Coherent Light Source (LCLS), came online. Due to the extreme brilliance and the ultrashort pulse duration of their X-ray radiation, XFELs are exceptionally well positioned to conduct time-resolved studies on biological macromolecules. Here, some of the pioneering experiments and recent results are summarized.
Keywords: Biological Macromolecules; Mix-and-Inject Serial Crystallography; Serial Femtosecond Crystallography; Structural Dynamics; Time-Resolved (Serial) Crystallography; X-ray Free Electron Laser.
© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2021.