Unfolding by Cdc48/p97: different strokes for different folks

Alexander Buchberger

doi:10.1016/j.tcb.2022.01.001

Unfolding by Cdc48/p97: different strokes for different folks

Trends Cell Biol. 2022 Apr;32(4):278-280. doi: 10.1016/j.tcb.2022.01.001. Epub 2022 Jan 17.

Author

Alexander Buchberger¹

Affiliation

¹ Department of Biochemistry, Biocenter, University of Würzburg, 97074 Würzburg, Germany. Electronic address: alexander.buchberger@uni-wuerzburg.de.

PMID: 35058103
DOI: 10.1016/j.tcb.2022.01.001

Abstract

The protein unfoldase Cdc48/p97 targets a wide variety of cellular substrates, but the molecular basis of substrate turnover remains incompletely understood. Two recent reports, by Ji et al. and van den Boom et al., provide detailed insights into the unfolding process and reveal pronounced flexibility of substrate handling by Cdc48/p97.

Keywords: AAA ATPase; protein phosphatase 1; proteinopathy; proteolysis; ubiquitin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Cycle Proteins* / metabolism
Humans
Protein Folding
Proteins* / metabolism
Valosin Containing Protein / chemistry
Valosin Containing Protein / metabolism

Substances

Cell Cycle Proteins
Proteins
Valosin Containing Protein