Cytomegalovirus and other herpesviruses after hematopoietic cell and solid organ transplantation: From antiviral drugs to virus-specific T cells

Tapuchova Ivana; Pytlik Robert; Simara Pavel; Tesarova Lenka; Koutna Irena

doi:10.1016/j.trim.2022.101539

Cytomegalovirus and other herpesviruses after hematopoietic cell and solid organ transplantation: From antiviral drugs to virus-specific T cells

Transpl Immunol. 2022 Apr:71:101539. doi: 10.1016/j.trim.2022.101539. Epub 2022 Jan 17.

Authors

Tapuchova Ivana¹, Pytlik Robert², Simara Pavel³, Tesarova Lenka⁴, Koutna Irena⁵

Affiliations

¹ Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czechia; International Clinical Research Center, St. Anne's University Hospital Brno, Pekarska 53, 656 91 Brno, Czechia. Electronic address: tapuchovai@gmail.com.
² Institute of Hematology and Blood Transfusion, Cell Therapy Department, U Nemocnice 2094/1, 128 00 Prague 2, Czechia.
³ Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 3, 625 00 Brno, Czechia; Institute of Hematology and Blood Transfusion, Cell Therapy Department, U Nemocnice 2094/1, 128 00 Prague 2, Czechia.
⁴ International Clinical Research Center, St. Anne's University Hospital Brno, Pekarska 53, 656 91 Brno, Czechia; Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 3, 625 00 Brno, Czechia.
⁵ Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czechia; International Clinical Research Center, St. Anne's University Hospital Brno, Pekarska 53, 656 91 Brno, Czechia; Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 3, 625 00 Brno, Czechia. Electronic address: qkoutna@gmail.com.

PMID: 35051589
DOI: 10.1016/j.trim.2022.101539

Abstract

Herpesviruses can either cause primary infection or may get reactivated after both hematopoietic cell and solid organ transplantations. In general, viral infections increase post-transplant morbidity and mortality. Prophylactic, preemptive, or therapeutically administered antiviral drugs may be associated with serious side effects and may induce viral resistance. Virus-specific T cells represent a valuable addition to antiviral treatment, with high rates of response and minimal side effects. Even low numbers of virus-specific T cells manufactured by direct selection methods can reconstitute virus-specific immunity after transplantation and control viral replication. Virus-specific T cells belong to the advanced therapy medicinal products, and their production is regulated by appropriate legislation; also, strict safety regulations are required to minimize their side effects.

Keywords: Adoptive transfer; Cytomegalovirus; Herpesviruses; Immunotherapy; Interferon gamma; Resistance; Virus-specific T cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antiviral Agents / therapeutic use
Cytomegalovirus
Hematopoietic Stem Cell Transplantation* / adverse effects
Organ Transplantation*
T-Lymphocytes

Substances

Antiviral Agents