How to Build and Regenerate a Functional Skin Barrier: The Adhesive and Cell Shaping Travels of a Keratinocyte

Marc Peskoller; Aishwarya Bhosale; Klaus Göbel; Julia Löhr; Stéphanie Miceli; Skyler Perot; Oana Persa; Matthias Rübsam; Jimit Shah; Hanyin Zhang; Carien M Niessen

doi:10.1016/j.jid.2021.12.034

How to Build and Regenerate a Functional Skin Barrier: The Adhesive and Cell Shaping Travels of a Keratinocyte

J Invest Dermatol. 2022 Apr;142(4):1020-1025. doi: 10.1016/j.jid.2021.12.034. Epub 2022 Jan 17.

Authors

Affiliations

¹ Department Cell Biology of the Skin, University Hospital of Cologne, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Stress Responses in Aging-associated Diseases (CECAD), University Hospital of Cologne, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, University of Cologne, Cologne, Germany.
² Department Cell Biology of the Skin, University Hospital of Cologne, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Stress Responses in Aging-associated Diseases (CECAD), University Hospital of Cologne, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, University of Cologne, Cologne, Germany; Department of Dermatology and Venerology, University Hospital of Cologne, University of Cologne, Cologne, Germany.
³ Department Cell Biology of the Skin, University Hospital of Cologne, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Stress Responses in Aging-associated Diseases (CECAD), University Hospital of Cologne, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, University of Cologne, Cologne, Germany. Electronic address: carien.niessen@uni-koeln.de.

PMID: 35051379
DOI: 10.1016/j.jid.2021.12.034

Abstract

In this perspective, we focus on the skin epidermis and take you on a journey that highlights the adhesive- and cell shape‒changing adventures of a keratinocyte while it travels through the different layers of the epidermis, which is essential to make, maintain, and repair this barrier.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adhesives*
Cell Shape
Epidermal Cells
Epidermis
Keratinocytes*

Substances

Adhesives