Immunotherapeutic Activities of a DNA Plasmid Carrying the Mycobacterial hsp65 Gene (DNAhsp65)

Celio Lopes Silva; Thiago Malardo; Aline Seiko Carvalho Tahyra

doi:10.3389/fmedt.2020.603690

Immunotherapeutic Activities of a DNA Plasmid Carrying the Mycobacterial hsp65 Gene (DNAhsp65)

Front Med Technol. 2020 Dec 15:2:603690. doi: 10.3389/fmedt.2020.603690. eCollection 2020.

Authors

Celio Lopes Silva^{1

2}, Thiago Malardo², Aline Seiko Carvalho Tahyra¹

Affiliations

¹ Department of Biochemistry and Immunology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
² Farmacore Biotecnologia Ltda, Ribeirão Preto, Brazil.

Abstract

DNA vaccines have become relevant subject matter, and efforts for their development have been increasing due to their potential as technology platforms applicable for prophylactic and therapeutic approaches for infectious diseases and for cancer treatment, allergies, and autoimmune diseases. This review aimed to summarize current knowledge about the plasmid DNA vaccine carrying the mycobacterial hsp65 gene (DNAhsp65), which demonstrates immunomodulatory and immunoregulatory properties of both the innate and adaptive immune systems. The possible mechanisms associated with the modulation and regulatory role of DNAhsp65 in the control of various conditions is also discussed.

Keywords: DNA vaccine; DNAhsp65; allergy; autoimmune diseases; cancer; heat-shock protein; immunotherapy; infectious diseases.

Publication types

Review