Pulmonary nodular lymphoid hyperplasia presenting as multifocal subsolid nodules: A case report and literature review

Abstract

Pulmonary nodular lymphoid hyperplasia (PNLH) is a rare, benign lymphoproliferative disease, which is characterized by nonclonal lymphoproliferation. PNLH is usually asymptomatic and usually detected incidentally on imaging studies. Common imaging findings include a solitary nodule, multiple nodules, or focal consolidation. Atypically, PNLH may present with persistent subsolid nodules, mimicking adenocarcinoma. Here, we report a rare case of PNLH presenting as multifocal subsolid nodules in both lower lobes. During follow-up, persistency and growth of the subsolid nodules suggested the possibility of malignancy. Wedge resection was performed bilaterally, and PNLH was confirmed on pathological examination.

Keywords: CT, Computed tomography; GGN, Ground glass nodule; LIP, Lymphoid interstitial pneumonia; Multidetector computed tomography; NSIP, Non-specific interstitial pneumonia; Nodular lymphoid hyperplasia; PNLH, Pulmonary nodular lymphoid hyperplasia; Subsolid nodule.