The exploration of promising anti-obesity influence of Zanthoxylum armatum (Rutaceae) is determined through our study of in-vitro and animal models. Obesity was induced in experimental albino rabbits by feeding highly fat diet (HFD) with regular feed for fortnight. The appraisal of anti-obesity of MZA and CZA extracts of leaves, fruit and stem of Z. armatum was performed in obese rabbits. Animals were divided into 04 groups. One group was categorized as control who received only HFD with no any extracts and drug. Other group was given orlistat orally a standard drug (10 mg/kg) in combination with the HFD regularly for 03 weeks and marked as positive control. Other 02 groups were allocated as experimental groups, 1st and 2nd experimental groups were administered daily 300 mg/kg of MZA and CMA extracts per oral route respectively for the same period. The substantial fall of lipid profile (total cholesterol, LDL, VLDL and TGs) and rise of HDL were perceived with methanolic extract on comparison to control groups. However, CMZ exhibited little response on serum lipid-profile. On conclusion, MZA extract of Z. armatum (areal parts) was considered a valid anti-obesity herbal remedy in experimental rabbits fed on high-feed diet.