Recent advances in induced proximity modalities

Christine S C Ng; Steven M Banik

doi:10.1016/j.cbpa.2021.102107

Recent advances in induced proximity modalities

Curr Opin Chem Biol. 2022 Apr:67:102107. doi: 10.1016/j.cbpa.2021.102107. Epub 2022 Jan 13.

Authors

Christine S C Ng¹, Steven M Banik²

Affiliations

¹ Department of Chemistry, Stanford University, Stanford, CA, USA.
² Department of Chemistry, Stanford University, Stanford, CA, USA; Stanford ChEM-H, Stanford University, Stanford, CA, USA. Electronic address: sbanik@stanford.edu.

PMID: 35033823
DOI: 10.1016/j.cbpa.2021.102107

Abstract

Challenging disease targets necessitate new approaches for therapeutic intervention. Rewiring protein-biomolecule interactions with proximity-inducing agents extends intervention opportunities beyond target agonism or inhibition. Spanning varied molecular phenotypes and diverse target classes, proximity-inducing agents demonstrate immense potential across target degradation, cleavage, and post-translational editing. Here, we review a selection of exciting developments in the concepts and mechanisms of induced proximity-driven strategies from the last two years. Key technological advances that enable these discoveries and expand the scope of targets and machinery for induced-proximity modalities are highlighted.

Keywords: Biologics; CRISPR; LYTAC; Molecular glue; PROTAC; Proteomics; Proximity; RIPR.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Protein Processing, Post-Translational*
Proteolysis
Proteomics*