ETS factors in prostate cancer

Cancer Lett. 2022 Apr 1:530:181-189. doi: 10.1016/j.canlet.2022.01.009. Epub 2022 Jan 14.

Abstract

The ETS family of proteins consists of 28 transcription factors, many of which play critical roles in both normal tissue development and homeostasis and have been implicated in development and progression of a variety of cancers. In prostate cancer, gene fusion and overexpression of ETS factors ERG, FLI1, ETV1, ETV4 and ETV5 have been found in half of prostate cancer patients in Caucasian men and define the largest genetic subtype of prostate cancer. This review summarizes the data on the discovery, modeling, molecular taxonomy, lineage plasticity and therapeutic targeting of ETS family members in prostate cancer.

Keywords: Androgen receptor; ERG; Oncogenic translocations; Prostate cancer; Transcription factors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Gene Expression / genetics
  • Humans
  • Male
  • Oncogene Proteins, Fusion / genetics
  • Prostatic Neoplasms / genetics*
  • Proto-Oncogene Proteins c-ets / genetics*
  • Transcription Factors / genetics*

Substances

  • Oncogene Proteins, Fusion
  • Proto-Oncogene Proteins c-ets
  • Transcription Factors