cCMP and cUMP come into the spotlight, finally

Roland Seifert; Bastian Schirmer

doi:10.1016/j.tibs.2021.12.008

cCMP and cUMP come into the spotlight, finally

Trends Biochem Sci. 2022 Jun;47(6):461-463. doi: 10.1016/j.tibs.2021.12.008. Epub 2022 Jan 11.

Authors

Roland Seifert¹, Bastian Schirmer²

Affiliations

¹ Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany. Electronic address: seifert.roland@mh-hannover.de.
² Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.

PMID: 35031198
DOI: 10.1016/j.tibs.2021.12.008

Abstract

cCMP and cUMP have been identified in numerous biological systems and proposed to serve as second messengers. However, this proposal remained controversial because of the base-promiscuity of generators, effectors, phosphodiesterases, and bacterial toxins. With the identification of specific cytidylyl and uridylyl cyclases, cCMP and cUMP research enters a new era.

Keywords: base-specificity; cCMP; cUMP; cytidylyl cyclase; second messenger; uridylyl cyclase.

MeSH terms

Cyclic CMP*
Nucleotides, Cyclic*
Second Messenger Systems
Uridine Monophosphate

Substances

Nucleotides, Cyclic
Cyclic CMP
cyclic 3',5'-uridine monophosphate
Uridine Monophosphate