FeOOH/Polypyrrole Nanocomposites with an Islands-in-Sea Structure toward Combined Photothermal/Chemodynamic Therapy

Wei Zhou; Haidi Guan; Kaiyao Sun; Yuxin Xing; Jixi Zhang

doi:10.1021/acsabm.9b00435

FeOOH/Polypyrrole Nanocomposites with an Islands-in-Sea Structure toward Combined Photothermal/Chemodynamic Therapy

ACS Appl Bio Mater. 2019 Jul 15;2(7):2708-2714. doi: 10.1021/acsabm.9b00435. Epub 2019 Jun 28.

Authors

Wei Zhou¹, Haidi Guan¹, Kaiyao Sun¹, Yuxin Xing¹, Jixi Zhang¹

Affiliation

¹ Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, No. 174 Shazheng Road, Chongqing 400044, China.

PMID: 35030806
DOI: 10.1021/acsabm.9b00435

Abstract

Simple integration of photothermal conversion agents (PTCAs) and Fenton catalysts within a single nanostructure is a challenge for combined photothermal therapy(PTT)/chemodynamic therapy (CDT). Herein, FeOOH/polypyrrole nanocomposites (NCs, ∼25 nm) with an islands-in-sea structure were synthesized in a simple interface-directed synthesis for combined therapy. The obtained NCs exhibit remarkable photothermal conversion efficiency (∼56%) resulting from doping and ordered packing of the π-conjugated polymer backbone as well as excellent catalytic performance in generating toxic hydroxyl radicals at low H₂O₂ concentrations mediated by the electron transfer from polypyrrole to FeOOH.

Keywords: Fenton catalyst; combined therapy; heterostructure; nanocomposites; photothermal conversion.