Abstract
Twelve new dimeric tetrahydroxanthones, muyocoxanthones A-L (1-12), were isolated from the endophytic fungus, Muyocopron laterale. Their structures were characterized on the basis of the interpretation of NMR and HRESIMS data. The absolute configurations of 1-10 and 12 were unambiguously determined by ECD spectrum data and single-crystal X-ray diffraction analysis. Compounds 2, 6, and 11 showed inhibitory activity against the LPS-induced production of nitric oxide (NO) in RAW 264.7 cells with IC50 values of 5.2, 1.3, and 5.1 μM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Ascomycota / chemistry*
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Carbon-13 Magnetic Resonance Spectroscopy
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Crystallography, X-Ray / methods
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Dimerization
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Macrophages / metabolism
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Mice
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Nitric Oxide / biosynthesis
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Proton Magnetic Resonance Spectroscopy
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RAW 264.7 Cells
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Spectrometry, Mass, Electrospray Ionization / methods
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Xanthones / pharmacology*
Substances
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Anti-Inflammatory Agents
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Lipopolysaccharides
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Xanthones
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Nitric Oxide