More fuel for the fire: Gut microbes and toxicity to immune agonist antibodies in cancer

Manoj Chelvanambi; Jennifer A Wargo

doi:10.1016/j.xcrm.2021.100482

More fuel for the fire: Gut microbes and toxicity to immune agonist antibodies in cancer

Cell Rep Med. 2021 Dec 21;2(12):100482. doi: 10.1016/j.xcrm.2021.100482.

Authors

Manoj Chelvanambi¹, Jennifer A Wargo^{1

2}

Affiliations

¹ Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
² Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

Abstract

Microbes in the gut impact response, resistance, and toxicity to numerous cancer therapies, though mechanisms remain incompletely understood. Blake et al. provide further evidence that gut microbes promote toxicity to immune-agonistic antibodies, with opportunities to target these in cancer treatment.¹.

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MeSH terms

Antibodies
Gastrointestinal Microbiome*
Humans
Neoplasms*

Substances

Antibodies