Nanoparticles caged with DNA nanostructures

Elizabeth Jergens; Jessica O Winter

doi:10.1016/j.copbio.2021.12.010

Nanoparticles caged with DNA nanostructures

Curr Opin Biotechnol. 2022 Apr:74:278-284. doi: 10.1016/j.copbio.2021.12.010. Epub 2022 Jan 10.

Authors

Elizabeth Jergens¹, Jessica O Winter²

Affiliations

¹ William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 151 W Woodruff Ave., Columbus, OH 43210, USA.
² William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 151 W Woodruff Ave., Columbus, OH 43210, USA; Department of Biomedical Engineering, The Ohio State University, 140 W. 19th Ave., Columbus, OH 43210, USA. Electronic address: winter.63@osu.edu.

PMID: 35026622
DOI: 10.1016/j.copbio.2021.12.010

Abstract

Nanoparticles (NPs) offer many benefits in biotechnology because of their small size and unique properties. However, many applications require precise positioning of the NPs or biological targeting molecules on their surfaces. DNA cages constructed from DNA tile, origami, or wireframe nanostructures offer a promising path forward because of their simplicity and programmability that can be used to generate complex, dynamic 2D and 3D geometries. Such materials can be used to pattern DNA on NP surfaces and organize NPs into specific supramolecular structures. DNA-caged NPs can be implemented in biosensing and drug delivery applications with cavities precisely designed to encapsulate-specific biomolecules. Ultimately, such approaches provide a springboard for future DNA robot designs that will enable controlled interactions with biological systems.

Publication types

Review
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

DNA / chemistry
Nanoparticles* / chemistry
Nanostructures* / chemistry
Nanotechnology
Nucleic Acid Conformation

Substances

DNA