Sequencing of Systemic Therapies in the Management of Advanced Prostate Cancer in India: a Delphi-Based Consensus

Chirag Desai; Ashok K Vaid; Ghanashyam Biswas; Sandeep Batra; Palanki S Dattatreya; Prabrajya Narayan Mohapatra; Deepak Dabkara; Adwaita Gore; Sagar B Bhagat; Saiprasad Patil; Hanmant Barkate

doi:10.1007/s40487-021-00181-1

Sequencing of Systemic Therapies in the Management of Advanced Prostate Cancer in India: a Delphi-Based Consensus

Oncol Ther. 2022 Jun;10(1):143-165. doi: 10.1007/s40487-021-00181-1. Epub 2022 Jan 13.

Authors

Affiliations

¹ Hemato-Oncology Clinic, HOC Vedanta, Ahmedabad, India.
² Medical Oncology and Hematology, Medanta-The Medicity, Gurugram, India.
³ Sparsh Hospital and Critical Care, Bhubaneswar, Odisha, India.
⁴ Medical Oncology, Max Superspeciality Hospital, Delhi, India.
⁵ Medical Oncology and Hemato Oncology, Omega Hospital, Hyderabad, India.
⁶ Medical Oncology, Apollo Glenagles, Kolkata, India.
⁷ Tata Medical Center, Kolkata, India.
⁸ Medical Oncology and Hemato-Oncology, Prince Aly Khan Hospital, Mumbai, India.
⁹ Global Medical Affairs, Glenmark Pharmaceutical Limited, Glenmark Corporate Enclave, BD Sawant Marg, Andheri East, Mumbai, 400099, Maharashtra, India. Sagar.Bhagat@glenmarkpharma.com.
¹⁰ Global Medical Affairs, Glenmark Pharmaceutical Limited, Glenmark Corporate Enclave, BD Sawant Marg, Andheri East, Mumbai, 400099, Maharashtra, India.

Abstract

Introduction: With the availability of an increasing number of therapeutic options for advanced prostate cancer (APC), optimal sequencing and combination of therapies have emerged to be the areas of challenges. In the Indian context, there is a dearth of consensus recommendations to guide clinicians regarding optimal sequencing of therapy in APC management. A Delphi-based consensus regarding optimal therapy sequencing in APC management was developed by an expert panel of medical oncologists from across India.

Methods: An expert scientific committee of 11 medical oncologists and an expert panel of 53 medical oncologists from India constituted the panel for the Delphi consensus. In the first phase, a questionnaire with 41 clinical statements was developed in several critical controversial areas in APC treatment. In the second phase, 29 clinical statements were reworked and sent to eight experts to obtain their opinions on best practices. The consensus ratings were based on a 9-point Likert scale. Based on the overall response, statements with a mean score of ≥ 7 with 1 outlier were considered as "consensus."

Results: Degarelix was the preferred androgen deprivation therapy (ADT). While ADT plus docetaxel was the preferred option for metastatic castrate-sensitive/naïve prostate cancer patients with high-volume disease, ADT with abiraterone was the preferred choice for low-volume disease. Docetaxel was the preferred first-line treatment option in men who received ADT alone in the castrate-sensitive/naïve setting. For patients progressing on or after docetaxel for metastatic castrate-resistant prostate cancer (without prior abiraterone or enzalutamide), the experts reached a consensus on the use of enzalutamide as the preferred second-line treatment option. No consensus was reached for the third-line treatment options.

Conclusion: This article is intended to serve as a guide to help clinicians discuss with their patients as part of the shared and multidisciplinary decision-making for improved APC management in India.

Keywords: Advanced prostate cancer; Androgen deprivation therapy; Castrate-resistant prostate cancer; Castrate-sensitive prostate cancer; Consensus; Delphi; India.