Biomarkers and Detection Platforms for Human Health and Performance Monitoring: A Review

Adv Sci (Weinh). 2022 Mar;9(7):e2104426. doi: 10.1002/advs.202104426. Epub 2022 Jan 12.

Abstract

Human health and performance monitoring (HHPM) is imperative to provide information necessary for protecting, sustaining, evaluating, and improving personnel in various occupational sectors, such as industry, academy, sports, recreation, and military. While various commercially wearable sensors are on the market with their capability of "quantitative assessments" on human health, physical, and psychological states, their sensing is mostly based on physical traits, and thus lacks precision in HHPM. Minimally or noninvasive biomarkers detectable from the human body, such as body fluid (e.g., sweat, tear, urine, and interstitial fluid), exhaled breath, and skin surface, can provide abundant additional information to the HHPM. Detecting these biomarkers with novel or existing sensor technologies is emerging as critical human monitoring research. This review provides a broad perspective on the state of the art biosensor technologies for HHPM, including the list of biomarkers and their physiochemical/physical characteristics, fundamental sensing principles, and high-performance sensing transducers. Further, this paper expands to the additional scope on the key technical challenges in applying the current HHPM system to the real field.

Keywords: biosensor technologies; human health and performance biomarkers; human health and performance monitoring.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Biomarkers
  • Biosensing Techniques*
  • Humans
  • Monitoring, Physiologic
  • Sweat
  • Wearable Electronic Devices*

Substances

  • Biomarkers