The association of long non-coding RNA in the prognosis of oral squamous cell carcinoma

Agnik Haldar; Ajay Kumar Singh

doi:10.1007/s13258-021-01194-w

The association of long non-coding RNA in the prognosis of oral squamous cell carcinoma

Genes Genomics. 2022 Mar;44(3):327-342. doi: 10.1007/s13258-021-01194-w. Epub 2022 Jan 13.

Authors

Agnik Haldar¹, Ajay Kumar Singh²

Affiliations

¹ Department of Bioinfomatics, Center for Biological Sciences (Bioinformatics), Central University of South Bihar, Panchanpur Road, Fathehpur, Tekari, Gaya, 824236, Bihar, India.
² Department of Bioinfomatics, Center for Biological Sciences (Bioinformatics), Central University of South Bihar, Panchanpur Road, Fathehpur, Tekari, Gaya, 824236, Bihar, India. ajaysingh@cusb.ac.in.

PMID: 35023067
DOI: 10.1007/s13258-021-01194-w

Abstract

Background: Oral cancer is considered one of the most prevalent cancers in India. This is mainly because India suffers from high usage of tobacco, which is one of the main causative agents of oral cancer, and lacks proper health and sexual hygiene in rural areas.

Discussion: Non-coding RNAs are reported to be involved in the various mechanism and causality of cancer. Numerous reports have identified viable prospects connecting non-coding RNA (ncRNA) with cancer. Specific ncRNAs like long non-coding RNA or lncRNAs are recently being prioritized as potential associations in the cause of cancer.

Conclusion: This review aims at presenting a concise perspective on the basics and the recent advancements of the lncRNA research pertaining specifically to oral cancer, its recurrence, and the future possibilities of knowledge it might possess.

Keywords: Epigenetics; Long non-coding RNA; Oral cancer.

Publication types

Review

MeSH terms

Humans
Mouth Neoplasms* / genetics
Prognosis
RNA, Long Noncoding* / genetics
RNA, Untranslated / genetics
Squamous Cell Carcinoma of Head and Neck* / genetics

Substances

RNA, Long Noncoding
RNA, Untranslated