Nanozyme-Augmented Tumor Catalytic Therapy by Self-Supplied H2O2 Generation

Xiaoling Li; Chang Zhao; Guang Deng; Wei Liu; Jing Shao; Zhiguo Zhou; Fang Liu; Hong Yang; Shiping Yang

doi:10.1021/acsabm.0c00056

Nanozyme-Augmented Tumor Catalytic Therapy by Self-Supplied H₂O₂ Generation

ACS Appl Bio Mater. 2020 Mar 16;3(3):1769-1778. doi: 10.1021/acsabm.0c00056. Epub 2020 Feb 27.

Authors

Xiaoling Li¹, Chang Zhao², Guang Deng¹, Wei Liu¹, Jing Shao¹, Zhiguo Zhou¹, Fang Liu², Hong Yang¹, Shiping Yang¹

Affiliations

¹ The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China.
² First Affiliated Hospital, Kunming Medical University, Kunming 650032, Yunnan, China.

PMID: 35021666
DOI: 10.1021/acsabm.0c00056

Abstract

Nanozyme with the "dual identity" of enzymes and nanomaterials is an emerging strategy to mimic natural enzymes in bio-nanotechnology. However, how to improve the nanozyme-based therapeutic efficiency in vivo still remains a challenge. Herein, we fabricated a nanozyme platform (Fe@Fe₃O₄@Cu_2-xS, named as MNPs) possessing peroxidase enzyme-like activity and then introduced β-lapachone (La) to assemble an effective nanozyme (LaMNPs) to boost the production of reactive oxygen species and upregulate the level of H₂O₂ by the released La in an acidic tumor microenvironment. As a proof of concept, LaMNPs were injected intravenously into mice model, resulting in a significant and efficient inhibition of the tumor growth.

Keywords: nanozyme; reactive oxygen species; self-supply; tumor therapy; β-lapachone.