ProSynAR: a reference aware read merger

Benjamin Crysup; Bruce Budowle; August E Woerner

doi:10.1093/bioinformatics/btac022

ProSynAR: a reference aware read merger

Bioinformatics. 2022 Mar 28;38(7):2052-2053. doi: 10.1093/bioinformatics/btac022.

Authors

Benjamin Crysup¹, Bruce Budowle¹, August E Woerner¹

Affiliation

¹ Center for Human Identification, University of North Texas, Fort Worth, TX 76107, USA.

PMID: 35020788
DOI: 10.1093/bioinformatics/btac022

Abstract

Motivation: Read-merging algorithms that look solely at the reads can misalign and mis-merge the reads (especially near repetitive sequences).

Results: The C++ program ProSynAR has been written to take the reads' position in the reference into account when performing (and deciding whether to perform) a merge.

Availability: *Nix users can retrieve the source from GitHub (https://github.com/Benjamin-Crysup/prosynar). Windows binary available at https://github.com/Benjamin-Crysup/prosynar/releases/download/1.0/prosynar.zip.

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Algorithms
High-Throughput Nucleotide Sequencing*
Repetitive Sequences, Nucleic Acid
Sequence Analysis, DNA
Software*

Abstract

Publication types

MeSH terms

Grants and funding