Abstract
Current photodynamic therapy (PDT) faces several intrinsic limitations, including insufficient oxygen supply and limited penetration of external light sources. Herein, we report a nanoconjugate, which, in response to the elevated hydrogen peroxide levels associated with tumor tissues, can supplement the oxygen needed for PDT and provide local self-illumination. Consisting of a MnFe2O4 core, a metal-organic framework shell loaded with the chemiluminescence reagent luminol, and a hyaluronic acid surface coating, the nanoconjugate is highly effective for suppressing cancer tissues in vivo via PDT in the absence of externally delivered light.
Keywords:
chemiluminescence; light-free; metal−organic framework (MOF); oxygen-supplemented; photodynamic therapy (PDT).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Biocompatible Materials / chemistry
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Biocompatible Materials / pharmacology*
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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Female
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Hep G2 Cells
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Humans
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Hyaluronic Acid / chemistry
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Hyaluronic Acid / pharmacology
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Hydrogen Peroxide / analysis
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Liver Neoplasms, Experimental / drug therapy
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Liver Neoplasms, Experimental / metabolism
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Liver Neoplasms, Experimental / pathology
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Luminol / chemistry
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Luminol / pharmacology
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Materials Testing
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Metal-Organic Frameworks / chemistry
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Metal-Organic Frameworks / pharmacology*
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Nanoconjugates / chemistry*
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Oxygen / chemistry
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Oxygen / pharmacology*
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Particle Size
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Photochemotherapy*
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Surface Properties
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Biocompatible Materials
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Metal-Organic Frameworks
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Nanoconjugates
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Luminol
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Hyaluronic Acid
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Hydrogen Peroxide
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Oxygen