Detailed short-term follow-up high-resolution CT series of differentiation syndrome

Tatsuya Oki; Yukihiro Nagatani; Wataru Saika; Yoshiyuki Watanabe

doi:10.1136/bcr-2021-242840

Detailed short-term follow-up high-resolution CT series of differentiation syndrome

BMJ Case Rep. 2022 Jan 10;15(1):e242840. doi: 10.1136/bcr-2021-242840.

Authors

Tatsuya Oki¹, Yukihiro Nagatani², Wataru Saika³, Yoshiyuki Watanabe¹

Affiliations

¹ Department of Radiology, Shiga University of Medical Science, Otsu, Shiga, Japan.
² Department of Radiology, Shiga University of Medical Science, Otsu, Shiga, Japan yatsushi@belle.shiga-med.ac.jp.
³ Department of Haematology, Shiga University of Medical Science, Otsu, Shiga, Japan.

Abstract

A 57-year-old man with acute promyelocytic leukaemia (APML) received induction therapy including all-trans-retinoic acid (ATRA). At day 15, he developed dyspnoea, haemoptysis and hypoxia. Thorax CT demonstrated diffuse ground-glass opacity and consolidation predominantly in dorsal regions, which may reflect increased vascular permeability. He was diagnosed with differentiation syndrome. After dexamethasone was administered and chemotherapy suspended, his symptoms improved and abnormal lesions mostly disappeared on follow-up CT examinations. We report a short-term high-resolution CT series of differentiation syndrome.

Keywords: drugs: respiratory system; haematology (drugs and medicines); haematology (incl blood transfusion); radiology.

Publication types

Case Reports

MeSH terms

Antineoplastic Combined Chemotherapy Protocols
Follow-Up Studies
Humans
Leukemia, Promyelocytic, Acute* / drug therapy
Male
Middle Aged
Syndrome
Tomography, X-Ray Computed
Tretinoin / therapeutic use

Substances

Tretinoin