Anxiolytic Effect and Improved Sleep Quality in Individuals Taking Lippia citriodora Extract

Nutrients. 2022 Jan 4;14(1):218. doi: 10.3390/nu14010218.

Abstract

The current fast-moving, hectic lifestyle has increased the number of individuals worldwide with difficulties in managing stress, which in turn is also affecting their sleep quality. Therefore, the objective of the current study was to assess a natural plant-based dietary supplement comprised of lemon verbena (Lippia citriodora) extract, purified in phenylpropanoids, in alleviating stress and improving quality of sleep. A double-blind, placebo-controlled study was conducted for 8 weeks, followed by a 4-week washout period. Both validated questionnaires and functional tests were performed during the study, whereas questionnaires were used after the washout. As a result, the group taking the lemon verbena extract significantly reduced their perception of stress after 8 weeks, which was corroborated by a significant decrease in cortisol levels. After the washout period, the subjects reported to present even lower stress levels, due to the lasting effect of the ingredient. As for sleep quality, the subjects taking the supplement reported feeling better rested, with a stronger effect observed in women. Sleep tracking using a wearable device revealed that the supplement users improved their times in the deeper stages of sleep, specifically their percentage of time in deep sleep and REM. In conclusion, lemon verbena extract purified in phenylpropanoids is revealed as a natural solution to help individuals to improve their stress and sleep quality.

Keywords: Mediterranean diet; anxiety; herbal plants; intelligent devices; natural antioxidants; natural extracts; sleep quality; stress.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Anxiety Agents*
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • Glucosides / administration & dosage
  • Humans
  • Lippia / chemistry*
  • Male
  • Middle Aged
  • Phenols / administration & dosage
  • Placebos
  • Plant Extracts / therapeutic use*
  • Plant Leaves / chemistry
  • Sleep Quality*
  • Spain
  • Stress, Psychological / drug therapy*
  • Surveys and Questionnaires

Substances

  • Anti-Anxiety Agents
  • Glucosides
  • Phenols
  • Placebos
  • Plant Extracts
  • acteoside