Recent years have witnessed rapidly growing interest in application of gene therapies for cancer treatment. However, this strategy requires nucleic acid carriers that are both effective and safe. In this context, non-viral vectors have advantages over their viral counterparts. In particular, lipopolyplexes-nanocomplexes consisting of nucleic acids condensed with polyvalent molecules and enclosed in lipid vesicles-currently offer great promise. In this article, we briefly review the major aspects of developing such non-viral vectors based on polyethyleneimine and outline their properties in light of anticancer therapeutic strategies. Finally, examples of current in vivo studies involving such lipopolyplexes and possibilities for their future development are presented.
Keywords: cancer; gene therapy; lipids; lipopolyplexes; liposomes; non-viral vectors; nucleic acids; polyethyleneimine.