Semi-interpenetrating Polyurethane Network Foams Containing Highly Branched Poly(N-isopropyl acrylamide) with Vancomycin Functionality

ACS Appl Bio Mater. 2021 May 17;4(5):4319-4327. doi: 10.1021/acsabm.1c00116. Epub 2021 Apr 27.

Abstract

Highly branched poly(N-isopropylacrylamide) (HB-PNIPAM), functionalized with vancomycin at the chain ends, acted as a bacterial adhesive and was incorporated into polyurethane foams to form semi-interpenetrating networks. PNIPAM was labeled with a solvatochromic dye, Nile red. It was found that the thermal response of the polymer was dependent on the architecture, and temperature-dependent color changes were observed within the foam. The foams had open pore structures, and the presence of HB-PNIPAM substantially reduced the shrinkage of the foam as the temperature was increased up to 20 °C. The foams were selectively adhesive for Staphylococcus aureus (Gram-positive bacteria) compared to Pseudomonas aeruginosa (Gram-negative bacteria), and the presence of S. aureus was indicated by increased fluorescence intensity (590-800 nm).

Keywords: Gram-positive bacteria; branched poly(N-isopropyl acrylamide); interpenetrating network; polyurethane; vancomycin; wound dressing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins / chemistry
  • Acrylic Resins / pharmacology*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / pharmacology*
  • Materials Testing
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Particle Size
  • Polyurethanes / chemistry
  • Polyurethanes / pharmacology*
  • Pseudomonas aeruginosa / drug effects
  • Staphylococcus aureus / drug effects
  • Vancomycin / chemistry
  • Vancomycin / pharmacology*

Substances

  • Acrylic Resins
  • Anti-Bacterial Agents
  • Biocompatible Materials
  • Polyurethanes
  • poly-N-isopropylacrylamide
  • Vancomycin