The Impact of Trace Elements on Osteoarthritis

Guoyong Li; Tao Cheng; Xuefeng Yu

doi:10.3389/fmed.2021.771297

The Impact of Trace Elements on Osteoarthritis

Front Med (Lausanne). 2021 Dec 23:8:771297. doi: 10.3389/fmed.2021.771297. eCollection 2021.

Authors

Guoyong Li¹, Tao Cheng², Xuefeng Yu¹

Affiliations

¹ Department of Orthopaedics, The Fourth Affiliated Hospital of Nanchang University, Nanchang, China.
² Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Abstract

Osteoarthritis (OA) is a progressive degenerative disease characterized by cartilage degradation, synovial inflammation, subchondral sclerosis and osteophyte formation. It has a multifactorial etiology with potential contributions from heredity, endocrine function, abnormal mechanical load and nutrition. Of particular considerations are trace element status. Several trace elements, such as boron and magnesium are essential for normal development of the bone and joint in human. While cadmium correlates with the severity of OA. The present review focuses on the roles of trace elements (boron, cadmium, copper, iron, magnesium, manganese, selenium, zinc) in OA and explores the mechanisms by which they act.

Keywords: deficiency; excess; osteoarthritis; role; trace elements.

Publication types

Review