The Effects of Delivery Mode on the Gut Microbiota and Health: State of Art

Chenchen Zhang; Lixiang Li; Biying Jin; Xinyan Xu; Xiuli Zuo; Yanqing Li; Zhen Li

doi:10.3389/fmicb.2021.724449

The Effects of Delivery Mode on the Gut Microbiota and Health: State of Art

Front Microbiol. 2021 Dec 23:12:724449. doi: 10.3389/fmicb.2021.724449. eCollection 2021.

Authors

Chenchen Zhang^{1

2

3}, Lixiang Li^{1

2

3}, Biying Jin^{1

2

3}, Xinyan Xu^{1

2

3}, Xiuli Zuo^{1

2

3}, Yanqing Li^{1

2

3}, Zhen Li^{1

2

3}

Affiliations

¹ Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
² Laboratory of Translational Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
³ Robot Engineering Laboratory for Precise Diagnosis and Therapy of GI Tumor, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Abstract

The delivery mode is an important factor driving alteration in the gut microbiota during the neonatal period. Several studies prove that the alteration of gut microbiota induced by cesarean section could influence the activation of intestinal epithelial cells and the development of immune system. Further, some autoimmune and metabolic disorders may be related to the microbiota dysbiosis in infants caused by cesarean section. It is noteworthy that probiotics could promote the intestinal microecology, which may further prevent and treat cesarean section related diseases. This review summarized the great significance of delivery mode on microbiota and health, as well as provided clinically feasible methods for the prevention and treatment of cesarean section related gut diseases.

Keywords: cesarean section; gut microbiota; immune system; intestinal epithelial cells; probiotics; vaginal delivery.

Publication types

Review