Association Between 18-FDG Positron Emission Tomography and MRI Biomarkers of Plaque Vulnerability in Patients With Symptomatic Carotid Stenosis

Nicola Giannotti; Jonathan McNulty; Shane Foley; John McCabe; Marey Barry; Morgan Crowe; Eamon Dolan; Joseph Harbison; Gillian Horgan; Eoin Kavanagh; Martin O'Connell; Michael Marnane; Sean Murphy; Ciaran Mc Donnell; Martin O'Donohoe; David Williams; Peter J Kelly

doi:10.3389/fneur.2021.731744

Association Between 18-FDG Positron Emission Tomography and MRI Biomarkers of Plaque Vulnerability in Patients With Symptomatic Carotid Stenosis

Front Neurol. 2021 Dec 23:12:731744. doi: 10.3389/fneur.2021.731744. eCollection 2021.

Authors

Nicola Giannotti¹, Jonathan McNulty¹, Shane Foley¹, John McCabe^{1

2}, Marey Barry³, Morgan Crowe^{1

4}, Eamon Dolan⁵, Joseph Harbison⁶, Gillian Horgan⁷, Eoin Kavanagh^{1

8}, Martin O'Connell^{1

8}, Michael Marnane^{1

2}, Sean Murphy², Ciaran Mc Donnell⁹, Martin O'Donohoe^{1

9}, David Williams¹⁰, Peter J Kelly^{1

2

6}

Affiliations

¹ School of Medicine, University College Dublin, Dublin, Ireland.
² Neurovascular Unit for Translational and Therapeutics Research, Mater Misericordiae University Hospital, Dublin, Ireland.
³ Vascular Surgery, St. Vincent's University Hospital, Dublin, Ireland.
⁴ Department of Medicine for the Elderly, St. Vincent's University Hospital, Stroke Service, Dublin, Ireland.
⁵ Stroke and Hypertension Unit, Connolly Hospital, Dublin, Ireland.
⁶ Acute Stroke Service, St. James Hospital Dublin, Trinity College Dublin, Dublin, Ireland.
⁷ Health Research Board (HRB) Stroke Clinical Trials Network Ireland, University College Dublin, Dublin, Ireland.
⁸ Department of Radiology, Mater Misericordiae University Hospital, Dublin, Ireland.
⁹ Department of Vascular Surgery, Mater Misericordiae University Hospital, Dublin, Ireland.
¹⁰ Geriatric Medicine, Beaumont Hospital and Royal College Surgeons Ireland, Dublin, Ireland.

Abstract

Purpose: Pathologic studies suggest that unstable plaque morphology and inflammation are associated with cerebrovascular events. ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸FDG-PET) is a validated technique for non-invasive imaging of inflammation-related plaque metabolism, and MRI can identify morphologic features of plaque instability. The aim of this study was to investigate the association of selected imaging characteristics of plaque vulnerability measured with MRI and PET in patients with symptomatic carotid stenosis. Methods: Patients from the BIOVASC study were selected based on the following inclusion criteria: (1) age ≥ 50 years; (2) recent (<30 days) ischaemic stroke (modified Rankin scale ≤3) or motor/speech/vision TIA; (3) ipsilateral internal carotid artery stenosis (≥5 0% lumen-narrowing); (4) carotid PET/CTA and MRI completed. Semi-automated plaque analysis of MRI images was performed to quantify morphologic features of plaque instability. PET images were co-registered with CTA and inflammation-related metabolism expressed as maximum standardised uptake value (SUV_max). Results: Twenty-five patients met inclusion criteria (72% men, mean age 65 years). MRI-measured plaque volume was greater in men (1,708-1,286 mm³, p = 0.03), patients who qualified with stroke (1,856-1,440 mm³, p = 0.05), and non-statin users (1,325-1,797 mm³, p = 0.03). SUV_max was associated with MRI-measured plaque lipid-rich necrotic core (LRNC) in the corresponding axial slice (r _s = 0.64, p < 0.001) and was inversely associated with whole-plaque fibrous cap thickness (r _s = -0.4, p = 0.02) and calcium volume (r _s = -0.4, p = 0.03). Conclusion: This study demonstrated novel correlations of non-invasive imaging biomarkers of inflammation-related plaque metabolism with morphological MRI markers of plaque instability. If replicated, our findings may support the application of combined MRI and PET to detect vulnerable plaque in future clinical practise and randomised trials.

Keywords: MRI; PET; atherosclerosis; carotid; plaque inflammation; plaque segmentation; vulnerable plaque biomarker.