Alcohol amplifies the association between common variants at PRSS1-PRSS2 locus and chronic pancreatitis in a dose-dependent manner

Gut. 2022 Nov;71(11):2369-2371. doi: 10.1136/gutjnl-2021-326670. Epub 2022 Jan 7.

Authors

Yuan-Chen Wang^{1

2}, Xiao-Tong Mao^{1

2}, Dong Yu³, Sheng-Han Mao^{1

2}, Zhao-Shen Li^{1

2}, Wen-Bin Zou^{4

2}, Zhuan Liao^{4

2}

Affiliations

¹ Department of Gastroenterology, Changhai Hospital, Shanghai, China.
² Shanghai Institute of Pancreatic Diseases, Shanghai, China.
³ Department of Precision Medicine, Translational Medicine Research Center, Second Military Medical University, Shanghai, China.
⁴ Department of Gastroenterology, Changhai Hospital, Shanghai, China liaozhuan@smmu.edu.cn dr.wenbinzou@hotmail.com.

PMID: 34996825
DOI: 10.1136/gutjnl-2021-326670

No abstract available

Keywords: chronic pancreatitis; genetic polymorphisms.

Publication types

Letter
Comment

MeSH terms

Genetic Predisposition to Disease
Humans
Mutation
Pancreatitis, Chronic* / genetics
Trypsin / genetics
Trypsinogen* / genetics

Substances

PRSS2 protein, human
Trypsinogen
PRSS1 protein, human
Trypsin