Serum short-chain fatty acids and its correlation with motor and non-motor symptoms in Parkinson's disease patients

Gang Wu; Zhengli Jiang; Yaling Pu; Shiyong Chen; Tingling Wang; Yajing Wang; Xiaoping Xu; Shanshan Wang; Minya Jin; Yangyang Yao; Yang Liu; Shaofa Ke; Suzhi Liu

doi:10.1186/s12883-021-02544-7

Serum short-chain fatty acids and its correlation with motor and non-motor symptoms in Parkinson's disease patients

BMC Neurol. 2022 Jan 7;22(1):13. doi: 10.1186/s12883-021-02544-7.

Authors

Gang Wu^{1

2}, Zhengli Jiang¹, Yaling Pu³, Shiyong Chen⁴, Tingling Wang², Yajing Wang², Xiaoping Xu², Shanshan Wang², Minya Jin⁴, Yangyang Yao⁵, Yang Liu^{2

6}, Shaofa Ke⁷, Suzhi Liu^{8

9}

Affiliations

¹ Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, 317000, Zhejiang, China.
² Department of Neurology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, 317000, Zhejiang, China.
³ Clinical Medical College, Shaoxing University of Arts and Sciences, Shaoxing, 312099, Zhejiang, China.
⁴ Clinical laboratory Department, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, 317000, Zhejiang, China.
⁵ Health Management Center, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, 317000, Zhejiang, China.
⁶ Department of Neurology, Saarland University, 66421, Homburg, Germany.
⁷ Department of Neurology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, 317000, Zhejiang, China. kesf@enzemed.com.
⁸ Department of Neurology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, 317000, Zhejiang, China. liusz@enzemed.com.
⁹ Clinical Medical College, Shaoxing University of Arts and Sciences, Shaoxing, 312099, Zhejiang, China. liusz@enzemed.com.

Abstract

Background: Parkinson's disease (PD) is associated with enteric nervous system dysfunction and gut microbiota dysbiosis. Short-chain fatty acids (SCFAs), derived from gut microbiota, are supposed to anticipate PD pathogenesis via the pathway of spinal cord and vagal nerve or the circulatory system. However, the serum concentration of SCFAs in PD patients is poorly known. This study aims to investigate the exact level of SCFAs in PD patients and its correlation with Parkinson's symptoms.

Methods: 50 PD patients and 50 healthy controls were recruited, and their demographic and clinical characteristics were collected. The serum concentration of SCFAs was detected using a gas chromatography-mass spectrometer. SCFAs were compared between PD and control groups. The correlation between serum SCFAs and Parkinson's symptoms and the potential effects of medications on the serum SCFAs was analyzed.

Results: Serum propionic acid, butyric acid and caproic acid were lower, while heptanoic acid was higher in PD patients than in control subjects. However, only the serum level of propionic acid was correlated with Unified Parkinson's Disease Rating Scale (UPDRs) part III score (R = -0.365, P = 0.009), Mini-mental State Examination (MMSE) score (R = -0.416, P = 0.003), and Hamilton Depression Scale (HAMD) score (R = 0.306, P = 0.03). There was no correlation between other serum SCFAs and motor complications. The use of trihexyphenidyl or tizanidine increased the serum concentration of propionic acid.

Conclusions: Serum SCFAs are altered in PD patients, and the decrease of serum propionic acid level is correlated with motor symptoms, cognitive ability and non-depressed state. Thus, the gut microbial-derived SCFAs potentially affect Parkinson's symptoms through the blood circulation. Propionic acid supplementation might ameliorate motor and non-motor symptoms of PD patients, although clinical trials are needed to test this hypothesis.

Keywords: Cognitive Impairment; Depression; Parkinson’s Disease; Propionic Acid; Short-Chain Fatty Acids; tizanidine; trihexyphenidyl.

MeSH terms

Cognition
Fatty Acids, Volatile
Gastrointestinal Microbiome*
Humans
Parkinson Disease* / drug therapy

Substances

Fatty Acids, Volatile