Key changes to the World Health Organization (WHO) classification of female genital tumours introduced in the 5th edition (2020)

Histopathology. 2022 Apr;80(5):762-778. doi: 10.1111/his.14609. Epub 2022 Feb 20.

Abstract

An updated World Health Organization (WHO) classification of female genital tumours was published in autumn 2020. We discuss the major new additions to and changes from the prior 2014 classification with a discussion of the reasons underlying these. A feature of the new classification is the greater emphasis on key molecular events with integration of morphological and molecular features. Most of the major changes from the prior classification pertain to uterine (corpus and cervix) and vulval tumours, but changes in all organs are covered.

Keywords: World Health Organization; cervix; endometrium; female genital tract; tubo-ovarian.

Publication types

  • Review

MeSH terms

  • Female
  • Genital Neoplasms, Female / classification*
  • Genital Neoplasms, Female / genetics
  • Genital Neoplasms, Female / pathology
  • Humans
  • World Health Organization