Cochlear and vestibular involvement in children with IgA vasculitis

Abdulkadir Bucak; Ayşegül Bükülmez; Selçuk Kuzu; Çağlar Günebakan; Erkan Yıldız; Abdullah Kınar

doi:10.1007/s00431-021-04331-5

Cochlear and vestibular involvement in children with IgA vasculitis

Eur J Pediatr. 2022 Apr;181(4):1481-1486. doi: 10.1007/s00431-021-04331-5. Epub 2022 Jan 7.

Authors

Abdulkadir Bucak¹, Ayşegül Bükülmez², Selçuk Kuzu³, Çağlar Günebakan¹, Erkan Yıldız⁴, Abdullah Kınar⁵

Affiliations

¹ Otorhinolaryngology Department, Otorhinolaryngology Clinic, Afyonkarahisar Health Sciences University Medical Faculty, 03300, Afyonkarahisar, Turkey.
² Pediatry Department, Afyonkarahisar Health Sciences University Medical Faculty, Afyonkarahisar, Turkey.
³ Otorhinolaryngology Department, Otorhinolaryngology Clinic, Afyonkarahisar Health Sciences University Medical Faculty, 03300, Afyonkarahisar, Turkey. dr.selcukkuzu@hotmail.com.
⁴ Otorhinolaryngology Department, Şuhut State Hospital, Afyonkarahisar, Turkey.
⁵ Otorhinolaryngology Department, Afyonkarahisar State Hospital, Afyonkarahisar, Turkey.

PMID: 34993623
DOI: 10.1007/s00431-021-04331-5

Abstract

In this study, our purpose is to evaluate cochlear and vestibular function in juveniles with IgA vasculitis using audiometry, distortion product otoacoustic emissions, and cervical vestibular evoked myogenic potential (cVEMP) tests. Forty children diagnosed with IgA vasculitis from the pediatry clinic and 40 age- and sex-matched healthy children were evaluated with distortion product otoacoustic emissions, audiometry, and cVEMP test in a tertiary hospital. The audiometry average values for both ears of the IgA vasculitis group and the control subjects were compared, and as a result, median 4.7-dB sensorineural hearing loss (SHL) was found for the IgA vasculitis group compared to the control group at 250 Hz and it was statistically significant (p < 0.001). An average of 6.4-dB SHL was detected at 8000 Hz (p < 0.001). There was a statistically significant difference among IgA vasculitis and control groups regarding measurement results of average p1-n1 latency time of both ears (0.9 ms (ms) increase, p = 0.035). In IgA vasculitis patients, the median amplitude difference of both ears' average p1 n1 was found to be 5.6 mV, statistically significantly decreased compared to the control group (p = 0.003).

Conclusion: This study, firstly in literature, demonstrated that IgA vasculitis may have association with hearing loss and vestibular dysfunction in children. We think this might be due to autoimmune mechanisms.

What is known: • Ig A vasculitis is a leukocytoclastic vasculitis with unknown etiology, involving the skin, joints, gastrointestinal system, kidneys, and rarely other organs. • No study has been reported for the cochlear and vestibular association of Ig A vasculitis in current literature.

What is new: • This study demonstrated that Ig A vasculitis may have association with hearing loss in children. • This study also demonstrated that Ig A vasculitis may have association with vestibular dysfunction in children.

Keywords: Childhood; DPOAE; Hearing; Ig A; Vasculitis; cVEMP.

MeSH terms

Audiometry
Case-Control Studies
Child
Hearing Loss, Sensorineural* / diagnosis
Hearing Loss, Sensorineural* / etiology
Humans
IgA Vasculitis* / complications
IgA Vasculitis* / diagnosis
Vestibular Evoked Myogenic Potentials* / physiology