GP73 links SARS-CoV-2 infection with dysglycaemia

Nat Metab. 2022 Jan;4(1):9-10. doi: 10.1038/s42255-021-00511-7.

Abstract

Severe COVID-19 is often associated with detrimental elevations in blood glucose, but the mechanisms are poorly understood. In this issue of Nature Metabolism, Wan et al. identify GP73 as a SARS-CoV-2-induced secreted factor that enhances hepatic glucose production and is necessary for SARS-CoV-2-associated glucose abnormalities.

Publication types

  • Lecture
  • Research Support, N.I.H., Extramural

MeSH terms

  • Biomarkers
  • Blood Glucose
  • COVID-19 / complications*
  • COVID-19 / virology*
  • Disease Susceptibility
  • Glucose / metabolism
  • Glucose Metabolism Disorders / diagnosis
  • Glucose Metabolism Disorders / etiology*
  • Glucose Metabolism Disorders / metabolism*
  • Host-Pathogen Interactions*
  • Humans
  • Liver / metabolism
  • Liver / pathology
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • SARS-CoV-2*

Substances

  • Biomarkers
  • Blood Glucose
  • GOLM1 protein, human
  • Membrane Proteins
  • Glucose