BACKGROUND: Over the next 20 yr, international market expansion will necessitate the production of new commercial airplanes and the recruitment of additional crewmembers and technicians. Research has proven that fatigue and lack of sleep are risk factors for impaired cognitive performance and human error. Pilots frequently report fatigue to their employers, which may be related to sleep disturbance. Airline pilots, in particular, often experience circadian desynchronization and other types of sleep disorders. Shift workers have been observed to be at higher risk of fatigue that affects their performance and alertness. In Saudi Arabia, sleep disorders among airline pilots are understudied and underreported. The primary objective of this study was to screen for and determine the risk of sleep disorders, fatigue, and depression among pilots.METHODS: A cross-sectional epidemiological study with national commercial pilots was conducted from March 2019 to March 2020 using validated questionnaires to screen for the risk of sleep disorders, fatigue, and depression.RESULTS: In total, 344 pilots participated in the study. Half the sample was at risk for insomnia and fatigue. Older and more experienced pilots were less likely to suffer impaired sleep quality, insomnia, sleepiness, fatigue, and depression. In total, 59 (17.2%) pilots were at high risk for sleep apnea.CONCLUSION: The current study found that pilots were at risk of developing sleep disorders. A more robust and objective assessment is warranted for screening.Alzehairi A, Alhejaili F, Wali S, Al Qassas I, Balkhyour M, Pandi-Perumal SR. Sleep disorders among commercial airline pilots. Aerosp Med Hum Perform. 2021; 92(12):937-944.