Thioether-directed Rh(III)-catalyzed peri-selective acyloxylation of arenes

Hui Xie; Jia-Lin Song; Chun-Yong Jiang; Yan-Xia Huang; Jun-Yi Zeng; Xu-Ge Liu; Shang-Shi Zhang; Fan Yang

doi:10.1039/d1ob02236a

Thioether-directed Rh(III)-catalyzed peri-selective acyloxylation of arenes

Org Biomol Chem. 2022 Jan 19;20(3):565-569. doi: 10.1039/d1ob02236a.

Authors

Hui Xie¹, Jia-Lin Song¹, Chun-Yong Jiang², Yan-Xia Huang¹, Jun-Yi Zeng¹, Xu-Ge Liu³, Shang-Shi Zhang¹, Fan Yang¹

Affiliations

¹ Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China. zhangshangshi@gdpu.edu.cn.
² School of Ethnic Medicine, Guizhou Minzu University, Guiyang, 550025, P. R. China.
³ Key Laboratory of Brain Targeted Nanodrugs of Henan Province, School of Pharmacy, Henan University, Kaifeng, Henan 475004, P. R. China. liuxg7@henu.edu.cn.

PMID: 34985096
DOI: 10.1039/d1ob02236a

Abstract

A thioether directed acyloxylation of arenes has been realized via Cp*Rh(III)-catalyzed C-H activation and subsequent coupling with carboxylic acids. This new method showed high functional group compatibility and broad substrate scope. Primary mechanistic studies have been conducted and a tentative reaction mechanism was proposed. It represents the first example of a thioether-directed Cp*Rh(III)-catalyzed C(sp²)-H acyloxylation reaction.

Publication types

Research Support, Non-U.S. Gov't