Dexamethasone ameliorates severe pneumonia but slightly enhances viral replication in the lungs of SARS-CoV-2-infected Syrian hamsters

Lunzhi Yuan; Ming Zhou; Jian Ma; Xuan Liu; Peiwen Chen; Huachen Zhu; Qiyi Tang; Tong Cheng; Yi Guan; Ningshao Xia

doi:10.1038/s41423-021-00793-7

Dexamethasone ameliorates severe pneumonia but slightly enhances viral replication in the lungs of SARS-CoV-2-infected Syrian hamsters

Cell Mol Immunol. 2022 Feb;19(2):290-292. doi: 10.1038/s41423-021-00793-7. Epub 2022 Jan 5.

Authors

Lunzhi Yuan^#¹, Ming Zhou^#¹, Jian Ma^#¹, Xuan Liu¹, Peiwen Chen^{2

3

4}, Huachen Zhu^{2

3

4}, Qiyi Tang⁵, Tong Cheng⁶, Yi Guan^{7

8

9}, Ningshao Xia^{10

11}

Affiliations

¹ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, Fujian, China.
² State Key Laboratory of Emerging Infectious Diseases, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China.
³ Guangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases, Joint Institute of Virology (STU/HKU), Shantou University, Shantou, Guangdong, China.
⁴ EKIH Pathogen Research Institute, Futian District, Shenzhen, Guangdong, China.
⁵ Department of Microbiology, Howard University College of Medicine, Washington, DC, USA.
⁶ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, Fujian, China. tcheng@xmu.edu.cn.
⁷ State Key Laboratory of Emerging Infectious Diseases, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China. yguan@hku.hk.
⁸ Guangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases, Joint Institute of Virology (STU/HKU), Shantou University, Shantou, Guangdong, China. yguan@hku.hk.
⁹ EKIH Pathogen Research Institute, Futian District, Shenzhen, Guangdong, China. yguan@hku.hk.
¹⁰ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, Fujian, China. nsxia@xmu.edu.cn.
¹¹ Research Unit of Frontier Technology of Structural Vaccinology, Chinese Academy of Medical Sciences, Xiamen, Fujian, China. nsxia@xmu.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter

MeSH terms

Animals
Anti-Inflammatory Agents / administration & dosage*
Antibodies, Viral / blood
COVID-19 / metabolism
COVID-19 / pathology
COVID-19 / virology
COVID-19 Drug Treatment*
Cricetinae
Dexamethasone / administration & dosage*
Disease Models, Animal
Injections, Intraperitoneal
Lung / metabolism
Lung / pathology
Lung / virology*
Male
Mesocricetus
RNA, Viral / genetics
RNA, Viral / metabolism
SARS-CoV-2 / genetics*
Treatment Outcome
Virus Replication / drug effects*

Substances

Anti-Inflammatory Agents
Antibodies, Viral
RNA, Viral
Dexamethasone

Grants and funding

U54 MD007597/MD/NIMHD NIH HHS/United States