Anti-obesity natural products and gut microbiota

Shang-Zhen Li; Su-Ling Zeng; E-Hu Liu

doi:10.1016/j.foodres.2021.110819

Anti-obesity natural products and gut microbiota

Food Res Int. 2022 Jan:151:110819. doi: 10.1016/j.foodres.2021.110819. Epub 2021 Nov 25.

Authors

Shang-Zhen Li¹, Su-Ling Zeng², E-Hu Liu³

Affiliations

¹ State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjia Lane, Nanjing 210009, China.
² Department of Medicine, University of California San Diego, La Jolla, CA, USA; Department of Medicine, VA San Diego Healthcare System, San Diego, CA, USA.
³ State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjia Lane, Nanjing 210009, China. Electronic address: liuehu2011@163.com.

PMID: 34980371
DOI: 10.1016/j.foodres.2021.110819

Abstract

The link between gut microbiota and obesity or other metabolic syndromes is growing increasingly clear. Natural products are appreciated for their beneficial health effects in humans. Increasing investigations demonstrated that the anti-obesity bioactivities of many natural products are gut microbiota dependent. In this review, we summarized the current knowledge on anti-obesity natural products acting through gut microbiota according to their chemical structures and signaling metabolites. Manipulation of the gut microbiota by natural products may serve as a potential therapeutic strategy to prevent obesity.

Keywords: Bacterial messengers; Gut microbiota; Natural products; Obesity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biological Products*
Gastrointestinal Microbiome*
Humans
Metabolic Syndrome*
Obesity

Substances

Biological Products