Identification of tumor tissue-derived DNA methylation biomarkers for the detection and therapy response evaluation of metastatic castration resistant prostate cancer in liquid biopsies

Thomas Dillinger; Raheleh Sheibani-Tezerji; Walter Pulverer; Ines Stelzer; Melanie R Hassler; Janine Scheibelreiter; Carlos Uziel Pérez Malla; Madeleine Kuroll; Sandra Domazet; Elisa Redl; Sarah Ely; Stefanie Brezina; Andreas Tiefenbacher; Katharina Rebhan; Nicolai Hübner; Bernhard Grubmüller; Markus Mitterhauser; Marcus Hacker; Andreas Weinhaeusel; Judit Simon; Markus Zeitlinger; Andrea Gsur; Gero Kramer; Shahrokh F Shariat; Lukas Kenner; Gerda Egger

doi:10.1186/s12943-021-01445-0

Identification of tumor tissue-derived DNA methylation biomarkers for the detection and therapy response evaluation of metastatic castration resistant prostate cancer in liquid biopsies

Mol Cancer. 2022 Jan 3;21(1):7. doi: 10.1186/s12943-021-01445-0.

Authors

Thomas Dillinger^{1

2}, Raheleh Sheibani-Tezerji^{1

2}, Walter Pulverer³, Ines Stelzer^{1

4}, Melanie R Hassler^{2

5}, Janine Scheibelreiter², Carlos Uziel Pérez Malla¹, Madeleine Kuroll¹, Sandra Domazet¹, Elisa Redl², Sarah Ely^{1

6}, Stefanie Brezina⁷, Andreas Tiefenbacher^{1

2}, Katharina Rebhan⁵, Nicolai Hübner⁵, Bernhard Grubmüller⁵, Markus Mitterhauser^{1

8}, Marcus Hacker⁸, Andreas Weinhaeusel³, Judit Simon^{1

4}, Markus Zeitlinger^{1

6}, Andrea Gsur⁷, Gero Kramer⁵, Shahrokh F Shariat^{5

9

10

11

12

13

14

15}, Lukas Kenner^{2

9

16

17}, Gerda Egger^{18

19

20}

Affiliations

¹ Ludwig Boltzmann Institute Applied Diagnostics, Vienna, Austria.
² Department of Pathology, Medical University of Vienna, Vienna, Austria.
³ Health & Environment Department, Molecular Diagnostics, AIT-Austrian Institute of Technology GmbH, Vienna, Austria.
⁴ Department of Health Economics, Center for Public Health, Medical University of Vienna, Vienna, Austria.
⁵ Department of Urology, Medical University Vienna, Vienna, Austria.
⁶ Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
⁷ Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
⁸ Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Vienna, Austria.
⁹ Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
¹⁰ Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
¹¹ Department of Urology, Weill Cornell Medical College, New York, NY, USA.
¹² Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
¹³ Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria.
¹⁴ Division of Urology, Department of Special Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan.
¹⁵ European Association of Urology Research Foundation, Arnhem, The Netherlands.
¹⁶ Unit of Laboratory Animal Pathology, University of Veterinary Medicine, Vienna, Austria.
¹⁷ Christian Doppler Laboratory for Applied Metabolomics, Medical University of Vienna, Vienna, Austria.
¹⁸ Ludwig Boltzmann Institute Applied Diagnostics, Vienna, Austria. gerda.egger@meduniwien.ac.at.
¹⁹ Department of Pathology, Medical University of Vienna, Vienna, Austria. gerda.egger@meduniwien.ac.at.
²⁰ Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. gerda.egger@meduniwien.ac.at.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor*
Computational Biology / methods
DNA Methylation*
Disease Management
Disease Susceptibility
Epigenesis, Genetic
Epigenomics / methods
Gene Expression Profiling
Humans
Liquid Biopsy* / methods
Male
Prognosis
Prostatic Neoplasms, Castration-Resistant / blood
Prostatic Neoplasms, Castration-Resistant / diagnosis*
Prostatic Neoplasms, Castration-Resistant / genetics*
Prostatic Neoplasms, Castration-Resistant / therapy
Treatment Outcome

Substances

Biomarkers, Tumor