Leptin to adiponectin ratio in puberty is associated with bone mineral density in 18-year-old males

Reeli Tamme; Jaak Jürimäe; Evelin Mäestu; Liina Remmel; Priit Purge; Eva Mengel; Vallo Tillmann

doi:10.1016/j.bonr.2021.101158

Leptin to adiponectin ratio in puberty is associated with bone mineral density in 18-year-old males

Bone Rep. 2021 Dec 13:16:101158. doi: 10.1016/j.bonr.2021.101158. eCollection 2022 Jun.

Authors

Reeli Tamme^{1

2}, Jaak Jürimäe³, Evelin Mäestu³, Liina Remmel³, Priit Purge³, Eva Mengel¹, Vallo Tillmann^{1

2}

Affiliations

¹ Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia.
² Children's Clinic of Tartu University Hospital, Tartu, Estonia.
³ Institute of Sports Sciences and Physiotherapy, Faculty of Medicine, University of Tartu, Tartu, Estonia.

Abstract

Introduction: Inconsistent associations of leptin and adiponectin with bone mineral characteristics in puberty and adolescence have been reported. We aimed to examine the associations between leptin to adiponectin ratio (LAR) in puberty and bone mineral characteristics at the age of 18 years in healthy males.

Materials and methods: 88 white Caucasian boys were investigated at T1 (mean age 12.1 years), T2 (14.0 years) and T3 (18.0 years). Serum leptin and adiponectin were measured and LAR was calculated at T1, T2 and T3, bone mineral density (BMD) and bone mineral apparent density (BMAD) for total body and lumbar spine (LS) at T1 and T3. Spearman correlation coefficient and partial correlation analyses were used to describe the associations between mean pubertal LAR and BMD at T3.

Results: Mean pubertal LAR was negatively correlated with both LS BMD (r = -0.23; P < 0.05) and LS BMAD at T3 (r = -0.33; P < 0.05). These associations remained significant also in partial correlation analysis after controlling for total body fat percentage, total testosterone, HOMA-IR and physical activity at T1 (r = -0.31; P < 0.05 and r = -0.41; P < 0.05 respectively).

Conclusion: LAR in puberty is negatively associated with lumbar spine BMD and lumbar spine BMAD at the age of 18 years.

Keywords: Adolescence; Bone mineral apparent density; Bone mineral density; Leptin to adiponectin ratio; Puberty.