Enteric glial cells mediate gut immunity and repair

Antonia Wallrapp; Daping Yang; Isaac M Chiu

doi:10.1016/j.tins.2021.12.001

Enteric glial cells mediate gut immunity and repair

Trends Neurosci. 2022 Apr;45(4):251-253. doi: 10.1016/j.tins.2021.12.001. Epub 2021 Dec 29.

Authors

Antonia Wallrapp¹, Daping Yang¹, Isaac M Chiu²

Affiliations

¹ Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
² Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. Electronic address: isaac_chiu@hms.harvard.edu.

PMID: 34973845
DOI: 10.1016/j.tins.2021.12.001

Abstract

In the gut, coordinated cell interactions regulate tissue repair and immunity. How enteric glial cells (EGCs) mediate these processes remained elusive. In a recent paper, Progatzky et al. demonstrate that EGCs interact with immune and mesothelial cells under homeostasis and helminth infection, revealing an indispensable role of an interferon-γ (IFNγ)-EGC-CXCL10 axis in tissue repair.

Keywords: CXCL10; IFNγ; enteric glial cells; helminth infection; immune homeostasis; tissue repair.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cell Communication
Enteric Nervous System*
Homeostasis
Humans
Neuroglia* / physiology

Abstract

Publication types

MeSH terms

Grants and funding