Bacterial cellulose-based biomaterials: From fabrication to application

Chuntao Chen; Weixiao Ding; Heng Zhang; Lei Zhang; Yang Huang; Mengmeng Fan; Jiazhi Yang; Dongping Sun

doi:10.1016/j.carbpol.2021.118995

Bacterial cellulose-based biomaterials: From fabrication to application

Carbohydr Polym. 2022 Feb 15:278:118995. doi: 10.1016/j.carbpol.2021.118995. Epub 2021 Dec 10.

Authors

Chuntao Chen¹, Weixiao Ding¹, Heng Zhang¹, Lei Zhang¹, Yang Huang², Mengmeng Fan³, Jiazhi Yang⁴, Dongping Sun⁵

Affiliations

¹ Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing, Jiangsu Province, China.
² Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing, Jiangsu Province, China; Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing, Jiangsu Province 210037, China.
³ Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing, Jiangsu Province 210037, China.
⁴ Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing, Jiangsu Province, China. Electronic address: jiazhiyang@sina.com.
⁵ Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing, Jiangsu Province, China. Electronic address: sundpe301@163.com.

PMID: 34973797
DOI: 10.1016/j.carbpol.2021.118995

Abstract

Driven by its excellent physical and chemical properties, BC (bacterial cellulose) has achieved significant progress in the last decade, rendering with many novel applications. Due to its resemblance to the structure of extracellular matrix, BC-based biomaterials have been widely explored for biomedical applications such as tissue engineering and drug delivery. The recent advances in nanotechnology endow further modifications on BC and generate BC-based composites for different applications. This article presents a review on the research advancement on BC-based biomaterials from fabrication methods to biomedical applications, including wound dressing, artificial skin, vascular tissue engineering, bone tissue regeneration, drug delivery, and other applications. The preparation of these materials and their potential applications are reviewed and summarized. Important factors for the applications of BC in biomedical applications including degradation and pore structure characteristic are discussed in detail. Finally, the challenges in future development and potential advances of these materials are also discussed.

Keywords: Application; Bacterial cellulose; Biodegradation; Biomaterials; Fabrication; Tissue engineering.

Publication types

Review

MeSH terms

Biocompatible Materials / chemistry*
Carbohydrate Conformation
Cellulose / chemistry*
Drug Delivery Systems*
Gram-Negative Bacteria / chemistry*
Tissue Engineering*

Substances

Biocompatible Materials
Cellulose