Interactions of Extracellular Vesicles from Pathogenic Fungi with Innate Leukocytes

Mateus Silveira Freitas; Andre Moreira Pessoni; Carolina Coelho; Vânia Luiza Deperon Bonato; Marcio L Rodrigues; Arturo Casadevall; Fausto Almeida

doi:10.1007/978-3-030-83391-6_9

Interactions of Extracellular Vesicles from Pathogenic Fungi with Innate Leukocytes

Curr Top Microbiol Immunol. 2021:432:89-120. doi: 10.1007/978-3-030-83391-6_9.

Authors

Mateus Silveira Freitas¹, Andre Moreira Pessoni¹, Carolina Coelho², Vânia Luiza Deperon Bonato¹, Marcio L Rodrigues^{3

4}, Arturo Casadevall⁵, Fausto Almeida⁶

Affiliations

¹ Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, SP, Brazil.
² MRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
³ Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, Brazil.
⁴ Instituto de Microbiologia Paulo de Góes (UFRJ), Rio de Janeiro, Brazil.
⁵ Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
⁶ Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, SP, Brazil. fbralmeida@usp.br.

PMID: 34972881
DOI: 10.1007/978-3-030-83391-6_9

Abstract

Several studies have shown the immunomodulatory effects of extracellular vesicles (EVs) released by pathogenic fungi. Herein, we discuss the data regarding the immunomodulatory properties of fungal EVs, but also of EVs produced by infected leukocytes. This characterizes a two-way path, in which both host and fungal EVs could coexist and play crucial roles in disease progression or protection in fungal infections. We suggest that EVs can dictate the progress of fungal diseases, and their potential as therapeutic targets.

MeSH terms

Extracellular Vesicles*
Fungi
Humans
Leukocytes
Mycoses*