Lessons Learned from Studying Histoplasma capsulatum Extracellular Vesicles

Daniel Zamith-Miranda; Lysangela Ronalte Alves; Ernesto Satoshi Nakayasu; Joshua Daniel Nosanchuk

doi:10.1007/978-3-030-83391-6_2

Lessons Learned from Studying Histoplasma capsulatum Extracellular Vesicles

Curr Top Microbiol Immunol. 2021:432:13-18. doi: 10.1007/978-3-030-83391-6_2.

Authors

Daniel Zamith-Miranda¹, Lysangela Ronalte Alves², Ernesto Satoshi Nakayasu³, Joshua Daniel Nosanchuk⁴

Affiliations

¹ Albert Einstein College of Medicine, Bronx, NY, USA.
² Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, Brazil.
³ Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
⁴ Albert Einstein College of Medicine, Bronx, NY, USA. josh.nosanchuk@einsteinmed.org.

PMID: 34972874
DOI: 10.1007/978-3-030-83391-6_2

Abstract

Histoplasma capsulatum is a major endemic mycosis. Our laboratories have demonstrated that H. capsulatum produces extracellular vesicles (EV) that are loaded with diverse compounds that influence virulence. We have further shown that H. capsulatum dynamically regulates the loading and release of fungal EV in response to stimuli and growth conditions. This chapter details the current knowledge of EV biology in H. capsulatum and the impact of this information on our understanding of this important process that is closely linked to pathogenesis.

Keywords: Extracellular vesicles; Histoplasma capsulatum; Proteomics; Serology.

MeSH terms

Extracellular Vesicles*
Histoplasma
Humans
Mycoses*
Virulence